Synthesis of a C14′, 15′ dihydro derivative of the south hexacyclic steroid unit of cephalostatin 1. Part I: Regiospecific Rh[II]-mediated intermolecular oxygen alkylation of a primary neopentyl alcohol

Article abstract of DOI:10.1016/0040-4039(95)01804-Q

Hecogenin acetate 5 was converted to an intermediate suitable for the construction of a C_{14′, 15′} dihydro derivative of the "South" hexacyclic spiroketal of cephalostatin 1 1. The key transformations include: (i) proximal functionalization of t