(2R,3S)- and (2S,3R)-2-benzyl-3,4-epoxybutanoic acid as highly efficient and fast acting pseudomechanism-based inactivators for carboxypeptidase A: design, asymmetric synthesis and inhibitory kinetics

DOI: 10.1039/P19950002877

Source and publish data:

Journal of the Chemical Society. Perkin transactions I p. 2877 - 2882 (1995)

Update date:2022-08-05

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Authors:

Lee, Soo Suk

Li, Zhi-Hong

Lee, Dong Ha

Kim, Dong H.

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Article abstract of DOI:10.1039/P19950002877

2-benzyl-3,4-epoxybutanoic acid (BEBA) was studied as an irreversible inhibitor for the zinc-containing protease, carboxypeptidase A.Of four possible stereoisomers, those having a 2R,3S- and a 2S,3R- configuration inhibited carboxypeptidase A in a time-de

Full text of DOI:10.1039/P19950002877

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