Preparation Involving a C4-C3 Ring Contraction in the Key Step of a Novel Cyclopropane Carbocyclic Nucleoside

Article abstract of DOI:10.1016/0040-4039(95)01536-1

Cis-3,4-bis(benzyloxymethyl)cyclobut-1-ene 1 mainly led to bromohydrin 5 with a cis relationship between bromine and the benzyloxymethyl groups.The stereospecific ring contraction of 5 afforded aldehyde 7 which could be converted into the nucleoside analo