Tetrahedron Letters p. 7507 - 7510 (1995)
Update date:2022-08-04
Topics:
Davis, Benjamin
Brandstetter, Tilmann W.
Smith, Colin
Hackett, Lucy
Winchester, Bryan G.
Fleet, George W. J.
The synthesis of tetrazoles derived from D-mannofuranose and both enantiomers of rhamnofuranose provides the first examples of tetrazole analogues of carbohydrates in the furanose form. The D-furanotetrazoles are potential mannosidase inhibitors whereas the L-rhamnotetrazole may interfere with the biosynthesis of cell walls of mycobacteria and provide a strategy for the treatment of tuberculosis and leprosy.
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