Asymmetric synthesis of 1-aryl-1,2,3,4-tetrahydroisoquinolines part 1: Addition of chiral phenylacetaldehyde acetals to acylimines

DOI: 10.1016/0040-4039(95)01716-U

Source and publish data:

Tetrahedron Letters p. 8003 - 8006 (1995)

Update date:2022-08-05

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Authors:

Wuensch, Bernhard

Nerdinger, Sven

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Article abstract of DOI:10.1016/0040-4039(95)01716-U

The stereoselectivity in the addition of the enantiomerically pure (2-bromophenyl)acetaldehyde acetals 3a-g to the acylimines 4a,b is investigated. Based on this reaction a novel asymmetric synthesis for the 1-phenyl-tetrahydroisoquinoline 8 is elaborated.

Full text of DOI:10.1016/0040-4039(95)01716-U

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