Synthesis of new fluorine-containing taxoids by means of β-lactam synthon method

Article abstract of DOI:10.1016/0040-4020(95)00865-6

A series of new fluorine-containing analogs of paclitaxel and docetaxel are synthesized using the coupling of (3R,4S)-1-acyl-β-lactams with high enantiomeric purity with properly protected baccatin III, 10-deacetylbaccatin III, and 14β-hydroxy-10-deacetyl