Synthesis of new fluorine-containing taxoids by means of β-lactam synthon method

DOI: 10.1016/0040-4020(95)00865-6

Source and publish data:

Tetrahedron p. 209 - 224 (1996)

Update date:2022-08-02

Topics:

Authors:

Ojima Ojima

Kuduk Kuduk

Slater Slater

Gimi Gimi

Sun Sun

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Article abstract of DOI:10.1016/0040-4020(95)00865-6

A series of new fluorine-containing analogs of paclitaxel and docetaxel are synthesized using the coupling of (3R,4S)-1-acyl-β-lactams with high enantiomeric purity with properly protected baccatin III, 10-deacetylbaccatin III, and 14β-hydroxy-10-deacetyl

Full text of DOI:10.1016/0040-4020(95)00865-6

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