Stereoselective total synthesis of lysocellin, the representative polyether antibiotic of the lysocellin family. Part 1. Synthesis of C1-C9 and C16-C23 subunits

Article abstract of DOI:10.1016/0040-4020(95)00905-1

The C1-C9 (4) and C16-C23 subunits (9) of lysocellin (1), a representative polyether antibiotic, were synthesized stereoselectively from D-glucose and D-mannitol. Stereocontrolled hydroboration, Michael reaction, Grignard reaction, etc. were successfully