Journal of Heterocyclic Chemistry p. 1461 - 1465 (1995)
Update date:2022-08-03
Topics:
Jagdmann Jr.
Chan
Styles
Tansik
Boytos
Rudolph
Several 5-(4-substituted benzyl)-2,4-diaminoquinazolines were prepared as potentially selective inhibitors of Candida albicans dihydrofolate reductase. These compounds were synthesized by a novel route, which included as a key step the displacement of a fluoro group in 2,6-difluorobenzonitrile by the anions of ethyl or methyl 4-substituted phenylacetates. The resultant diarylacetates were saponified and decarboxylated to the 2-fluoro-6-(4-substituted phenyl)benzonitriles. Ring closure of these benzonitriles with guanidine carbonate gave the 5-(4-substituted benzyl)-2,4-diaminoquinazolines.
View MoreContact:+86-533-3112891
Address:zibo
Contact:+86-512-56795332
Address:No227 Shuanglong Rd, Fenghuang, Zhangjiagang
Contact:+86-519-86339586,13584329896
Address:Changzhou Scientific and Education Park
Contact:+86-025-52406782
Address:8 Taizishan Rd., Yanjiang Industrial Development Area, Nanjing, Jiangsu, China.
Jiangsu Zenji Pharmaceuticals LTD
Contact:+86-025-83172562; +1-224-888-1133(USA)
Address:No.5 Xinmofan Road
Doi:10.1039/c39950002429
(1995)Doi:10.1021/jacs.5b05934
(2015)Doi:10.1016/S0022-328X(00)00003-6
(2000)Doi:10.1016/S0040-4039(01)88935-8
(1969)Doi:10.1016/S0040-4020(99)01102-3
(2000)Doi:10.1055/s-2000-6343
(2000)