Journal of Heterocyclic Chemistry p. 1461 - 1465 (1995)
Update date:2022-08-03
Topics:
Jagdmann Jr.
Chan
Styles
Tansik
Boytos
Rudolph
Several 5-(4-substituted benzyl)-2,4-diaminoquinazolines were prepared as potentially selective inhibitors of Candida albicans dihydrofolate reductase. These compounds were synthesized by a novel route, which included as a key step the displacement of a fluoro group in 2,6-difluorobenzonitrile by the anions of ethyl or methyl 4-substituted phenylacetates. The resultant diarylacetates were saponified and decarboxylated to the 2-fluoro-6-(4-substituted phenyl)benzonitriles. Ring closure of these benzonitriles with guanidine carbonate gave the 5-(4-substituted benzyl)-2,4-diaminoquinazolines.
View Morewebsite:http://www.uvchemkeys.com
Contact:0086-021-58785816
Address:RM2607 Building No.1 Guosheng, Lane 388, Zhongjiang Road, Putuo District, Shanghai 200062 China
jiangsu hualin chemical co.,ltd.
Contact:86-25-87787402
Address:jaingsu,china
Contact:+86-10-67147360/67107388
Address:No.18 Guangming Zhongjie, Chongwen District, Beijing, 100061, China
wuxi huabin bio-tech Co.,Ltd(expird)
Contact:86-0510-85133006
Address:hubin road NO157
Guangxi Bonger Pharmaceutical Co., Ltd
website:http://napo.lookchem.com/
Contact:+86-18817331185
Address:Donghai Industrial Zone, Tiandong Country,Guangxi,China
Doi:10.1039/c39950002429
(1995)Doi:10.1021/jacs.5b05934
(2015)Doi:10.1016/S0022-328X(00)00003-6
(2000)Doi:10.1016/S0040-4039(01)88935-8
(1969)Doi:10.1016/S0040-4020(99)01102-3
(2000)Doi:10.1055/s-2000-6343
(2000)