3-pyridylethanolamines: Potent and selective human β3 adrenergic receptor agonists

Article abstract of DOI:10.1016/S0960-894X(98)00571-X

The 3-pyridylethanolamine L-757,793 is a potent β₃ AR agonist (EC₅₀ 6.3 nM, 70% activation) with 1,300- and 500-fold selectivity over binding to the β₁ and β₂ ARs, respectively. L-757,793 stimulated lipolysis in rhesus monkeys (ED₅₀ 0.2 mg/kg) with a maximum response equivalent to that elicited by isoproterenol.