Bioorganic and Medicinal Chemistry Letters p. 3087 - 3092 (1998)
Update date:2022-07-30
Topics:
Naylor, Elizabeth M.
Colandrea, Vincent J.
Candelore, Mari R.
Cascieri, Margaret A.
Colwell Jr., Lawrence F.
Deng, Liping
Feeney, William P.
Forrest, Michael J.
Hom, Gary J.
MacIntyre, D. Euan
Strader, Catherine D.
Tota, Laurie
Wang, Pei-Ran
Wyvratt, Matthew J.
Fisher, Michael H.
Weber, Ann E.
The 3-pyridylethanolamine L-757,793 is a potent β3 AR agonist (EC50 6.3 nM, 70% activation) with 1,300- and 500-fold selectivity over binding to the β1 and β2 ARs, respectively. L-757,793 stimulated lipolysis in rhesus monkeys (ED50 0.2 mg/kg) with a maximum response equivalent to that elicited by isoproterenol.
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