Asymmetric reduction of 2-(N-arylimino)-3,3,3-trifluoropropanoic acid esters leading to enantiomerically enriched 3,3,3-trifluoroalanine

DOI: 10.1016/0040-4020(95)00866-7

Source and publish data:

Tetrahedron p. 233 - 244 (1996)

Update date:2022-08-03

Topics:

Authors:

Sakai, Takashi

Yan, Fengyang

Kashino, Setsuo

Uneyama, Kenji

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Article abstract of DOI:10.1016/0040-4020(95)00866-7

Enantiomerically enriched 3,3,3-trifluoroalanine (1) (up to 62 % ee) has been synthesized by the asymmetric reduction of 2-(N-arylimino)-3,3,3-trifluoropropanoic acid esters with a chiral oxazaborolidne catalyst and subsequent oxidative removal of N-aroma

Full text of DOI:10.1016/0040-4020(95)00866-7

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