N2-(p-n-Octylphenyl)dGTP: Synthesis and inhibitory activity against DNA polymerases

DOI: 10.1080/07328319608002414

Source and publish data:

Nucleosides and Nucleotides p. 669 - 682 (1996)

Update date:2022-08-03

Topics:

Authors:

Jansons, Janis

Stattel, James

Verri, Annalisa

Gambino, Joseph

Khan, Naseema

Focher, Federico

Spadari, Silvio

Wright, George

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Article abstract of DOI:10.1080/07328319608002414

N²-(p-n-Octylphenyl)-2'-deoxyguanosine 5'-triphosphate (OctPdGTP) has been synthesized chemically. OctPdGTP inhibited DNA polymerase (pol) α, δ and ε from calf thymus, with moderate selectivity for pol α. Mechanistic studies on pol α and bacter

Full text of DOI:10.1080/07328319608002414

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