A formal synthesis of castanospermine using an olefin metathesis cyclisation reaction as a key step

DOI: 10.1016/0040-4039(95)02237-6

Source and publish data:

Tetrahedron Letters p. 547 - 550 (1996)

Update date:2022-08-04

Topics:

Authors:

Overkleeft, Herman S.

Pandit, Upendra K.

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Article abstract of DOI:10.1016/0040-4039(95)02237-6

The formal synthesis of castanospermine (1) starting from tetrabenzylgluconolactam (3) is described. Olefin metathesis cyclisation reaction of dialkene 9, derived from 3, leads to indolizidinone 10, which can be used as a key intermediate for the synthesis of castanospermine (1) and its analogues.

Full text of DOI:10.1016/0040-4039(95)02237-6

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