1,2,3-Triazolo[4,5-e]-1,2,4-triazolo[3,4-c]pyrimidines

Article abstract of DOI:10.1002/jhet.5570360514

Some new 1,2,3-triazolo[4,5-e]-1,2,4-triazolo[3,4-c]pyrimidines were prepared starting from the corresponding 1,2,3-triazolo[4,5-d]pyrimidines via the formation of the 1,2,4-triazole ring. Thus suitable hydrazino derivatives 6 were condensed with triethyl orthoformate, triethyl orthoacetate and triethyl orthobenzoate to give the expected tricyclic derivatives 7, 8 and 9. Intramolecular cyclization of the ethoxycarbonylhydrazino derivatives 10 gave the tricyclic compounds 11 bearing an hydroxyl group in the 3 position. The v-triazolo-s-triazolopyrimidine derivatives were tested towards the A₁ and A(2A) adenosine receptors in binding assays, but they did not show any receptor affinity.