Bioorganic and Medicinal Chemistry Letters p. 1345 - 1348 (1997)
Update date:2022-08-02
Topics:
Dinsmore, Christopher J.
Williams, Theresa M.
Hamilton, Kelly
O'Neill, Timothy J.
Rands, Elaine
Koblan, Kenneth S.
Kohl, Nancy E.
Gibbs, Jackson B.
Graham, Samuel L.
Hartman, George D.
Oliff, Allen I.
The design and synthesis of simple nonpeptide inhibitors of farnesyl-protein transferase (FTase) are described. Cysteine-derived diarylether frameworks are appropriate structural replacements for the C-terminal tetrapeptide portion of the Ras protein, and possess in vitro potency against FTase. Inhibitory activity is dependent on the ring-substitution pattern, and does not require the presence of a C-terminal carboxylate group.
View MoreDalian RSD International Trade Co.,Ltd.(expird)
Contact:86-22-60875058 58610575
Address:Wantong International Areas, Hongqiao District, Tianjin, China.China
Anhui Eapearl Chemical Co., Ltd.
Contact:86-562-5858458
Address:358 South Huaihe Road
website:http://www.sagechem.com
Contact:+86-571-86818502
Address:Room C1301, New Youth Plaza, 8 Jia Shan Road, Hangzhou, China
Hangzhou Yanshan Chemical Co.,Ltd.
Contact:86-571- 87698076
Address:Room 1001, #1 Building, Zhongtian MCC, No.2 Youzhinong, Wenyi West Road, Xihu District, Hangzhou, China
Guangzhou Probig Fine Chemical Co., Ltd.
Contact:020-86297874
Address:No.2, 1/F, No.20, Hetai Road,Hebian Village, Baiyun District,Guangzhou,China
Doi:10.1016/0960-894X(95)00580-M
(1996)Doi:10.1021/ol101012n
(2010)Doi:10.1016/S0022-1139(00)81035-0
(1988)Doi:10.1021/jo1024199
(2011)Doi:10.1007/s00044-010-9321-6
(2011)Doi:10.1039/b919625k
(2010)
