Bioorganic and Medicinal Chemistry Letters p. 1345 - 1348 (1997)
Update date:2022-08-02
Topics:
Dinsmore, Christopher J.
Williams, Theresa M.
Hamilton, Kelly
O'Neill, Timothy J.
Rands, Elaine
Koblan, Kenneth S.
Kohl, Nancy E.
Gibbs, Jackson B.
Graham, Samuel L.
Hartman, George D.
Oliff, Allen I.
The design and synthesis of simple nonpeptide inhibitors of farnesyl-protein transferase (FTase) are described. Cysteine-derived diarylether frameworks are appropriate structural replacements for the C-terminal tetrapeptide portion of the Ras protein, and possess in vitro potency against FTase. Inhibitory activity is dependent on the ring-substitution pattern, and does not require the presence of a C-terminal carboxylate group.
View MoreContact:13357117572
Address:No.149 Shiji dadao Road.
Contact:0086 16537861366
Address:building 17, shibei district Qingdao, shandong china
Chemtrade International ( China )
Contact:+86-532-86893005
Address:Rm 2-501, Huaxia Zonghe Building, No. 410 JInggangshan Road, Huangdao
Chongqing Shuangfeng Chemical Co.,Ltd
Contact:+86-23-49850156
Address:No.663,xuanhua Rd,yongchuan,chongqing,China
QINGDAO DEVELOP chemistry Co.,Limited
Contact:+86-532-85807910
Address:98#Nanjing Road, Qingdao, China 266071
Doi:10.1016/0960-894X(95)00580-M
(1996)Doi:10.1021/ol101012n
(2010)Doi:10.1016/S0022-1139(00)81035-0
(1988)Doi:10.1021/jo1024199
(2011)Doi:10.1007/s00044-010-9321-6
(2011)Doi:10.1039/b919625k
(2010)
