European Journal of Medicinal Chemistry p. 955 - 962 (1995)
Update date:2022-08-03
Topics:
Wahbi, Y.
Caujolle, R.
Tournaire, C.
Payard, M.
Linas, M. D.
Seguela, J. P.
Aromatic ethers related to antifungal azole miconazole were synthesized and tested against various strains of Candida.We found that activity is related to the nature of the aromatic ring and the position of substituents on this ring.Activity is more strongly dependent on the substituent in the 2-position of the ethyl chain on the aromatic group linked through the oxygen.Triazoles were always less potent than the corresponding imidazole analogues. - Keywords: imidazole; 1,2,4-triazole; antifungal activity; yeast; structure-activity relationship
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