Synthesis of 1,5-anhydrohexitol nucleosides as mimics of AZT, D4T and DDC

Article abstract of DOI:10.1080/07328319608002387

1,5-Anhydrohexitol congeners of AZT, D4T and DDC were synthesized. These compounds did not show anti-HIV activity.

Full text of DOI:10.1080/07328319608002387

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Nucleosides and Nucleotides
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Synthesis of 1,5-Anhydrohexitol
Nucleosides as Mimics of AZT, D4T and
DDC
Ilse Verheggen a , Arthur Van Aerschot a , Jef Rozenski a , Gerard
Janssen a , Erik De Clercq b & Piet Herdewijn a
a Laboratory of Medicinal Chemistry, Rega Institute for Medical
Research , K. U. Leuven, Minderbroedersstraat 10, B-3000,
Leuven, Belgium
b Laboratory of Experimental Chemotherapy, Rega Institute
for Medical Research , K. U. Leuven, Minderbroedersstraat 10,
B-3000, Leuven, Belgium
Published online: 21 Aug 2006.
To cite this article: Ilse Verheggen , Arthur Van Aerschot , Jef Rozenski , Gerard Janssen , Erik De
Clercq & Piet Herdewijn (1996) Synthesis of 1,5-Anhydrohexitol Nucleosides as Mimics of AZT, D4T
and DDC , Nucleosides and Nucleotides, 15:1-3, 325-335
To link to this article: http://dx.doi.org/10.1080/07328319608002387
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