Bioorganic and Medicinal Chemistry Letters p. 339 - 344 (1996)
Update date:2022-08-03
Topics:
Xue
Rafalski
Roderick
Eyermann
Mousa
Olson
DeGrado
A potent centrally constrained series of benzimidazole and benzoxazole glycoprotein IIb/IIIa inhibitors has been discovered based on the solution conformation of a cyclic RGD-containing peptide, DMP 728. The high potency of this series of compounds in the inhibition of platelet aggregation requires a benzamidine as the basic moiety and an α-carbamate or sulfonamide substituted β-alanine as the acidic moiety.
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(1996)