Formal total syntheses of the β-lactam antibiotics thienamycin and PS-5

Article abstract of DOI:10.1021/jo952092u

Chiral nonracemic acetylenic acids of general structure 11, prepared using the Schreiber modification of the Nicholas reaction, have been converted to β-amino acid derivatives of type 12 by a two-step sequence involving Curtius rearrangement followed by o