Synthesis of 5-phosphate-D-arabinohydroxamic acid, a potent transition state analogue inhibitor of 6-phosphate-D-glycose isomerases

DOI: 10.1016/0040-4039(96)00004-4

Source and publish data:

Tetrahedron Letters p. 1221 - 1224 (1996)

Update date:2022-08-03

Topics:

Authors:

Bonnette

Salmon Salmon

Gaudemer

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Article abstract of DOI:10.1016/0040-4039(96)00004-4

The first hydroxamate-based and potent transition state analogue (TSA) inhibitor of 6-phosphate-D-glucose isomerases, 5-phosphate-D-arabinohydroxamic acid 3, has been synthesized by conversion of D-arabinose to a protected derivative of 5-phosphate-D-arabinonic acid and introduction of the hydroxamine group by coupling with O-benzylhydroxylamine.

Full text of DOI:10.1016/0040-4039(96)00004-4

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