Unsaturated thioacetic acids as novel mechanism-based inhibitors of peptidylglycine α-hydroxylating monooxygenase

DOI: 10.1016/0960-894X(96)00041-8

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 393 - 396 (1996)

Update date:2022-08-05

Topics:

Authors:

Casara Casara

Ganzhorn

Philippo

Chanal Chanal

Danzin Danzin

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/0960-894X(96)00041-8

Several unsaturated thioacetic acids were synthesized as potential mechanism-based inhibitors of peptidylglycine α-hydroxylating monooxygenase (PHM) prepared from horse serum. Trans-styrylthioacetic acid produced potent time-dependent inhibition of PHM. Potential mechanisms are proposed to explain PHM inactivation by unsaturated thioacetic acids.

Full text of DOI:10.1016/0960-894X(96)00041-8

Products guided by the article

Product name:(2-Hydroxy-2-phenyl-ethylsulfanyl)-acetic acid methyl ester

Cas No:175911-35-0

R&D Labs maybe for 175911-35-0

Lian Xing Chemical Co.,Ltd.

Contact:0792-8228321

Address:10TH Floor No.121 binjiang Road Xunyang District
Nanjing Spring & Autumn Biological Engineering Co., Ltd.

Contact:86-180510-83338

Address:Suite# 210, No. 1 BuildingNanjing Agricultural Biotechnology High-tech Entrepreneurship Center, No. 4 Tongwei Road, Xuanwu District, Nanjing,China
Arshine Pharmaceutical Co., Limited

website:http://www.cnarshine.com

Contact:0731-88503671

Address:Room 1109.Block C3, Lugu Enterprise Plaza,No.27 Wenxuan Road,Changsha National Hi-Tech Industrial Development Zone,Hunan ,P.R.China
Shanghai Yuantai Chemical Products Co., Ltd

Contact:021--66129803

Address:Chengyin Road,Shanghai,China
Skyrun Industrial Co.,Ltd(expird)

website:http://www.chinaskyrun.com

Contact:0086-576-84610586

Address:Chemical Development Zone

Relevant to this article

Enantioselective syntheses of (R)- and (S)-hexahydropyridazine-3-carboxylic acid derivatives

Doi:10.1055/s-1996-4192
(1996)
Synthesis of pyrrolizidine bases by highly diastereoselective and regioselective catalytic carbon-hydrogen insertion reactions of chiral pyrrolidinediazoacetamides

Doi:10.1016/0040-4039(96)00056-1
(1996)
Intramolecular acylations of γ-benzoyloxy phosphine oxides: Synthesis of optically active cyclopropyl ketones

Doi:10.1016/0040-4039(96)00049-4
(1996)
Inter- and intra-molecular selectivity in the cyclisation of N-cinnamoyl-1-naphthamides in solid-state photochemistry and peri selectivity in their photocyclisation in solution

Doi:10.1039/p19960000529
(1996)
New arylhexahydropyrimidinediones: Synthesis, benzodiazepine receptor affinity and anticonvulsant activity

Doi:10.1016/0223-5234(96)80371-0
(1996)
An R-selective hydroxynitrile lyase from Arabidopsis thaliana with an α/β-hydrolase fold

Doi:10.1002/anie.200701455
(2007)

Article Doi