Unsaturated thioacetic acids as novel mechanism-based inhibitors of peptidylglycine α-hydroxylating monooxygenase

DOI: 10.1016/0960-894X(96)00041-8

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 393 - 396 (1996)

Update date:2022-08-05

Topics:

Authors:

Casara Casara

Ganzhorn

Philippo

Chanal Chanal

Danzin Danzin

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Article abstract of DOI:10.1016/0960-894X(96)00041-8

Several unsaturated thioacetic acids were synthesized as potential mechanism-based inhibitors of peptidylglycine α-hydroxylating monooxygenase (PHM) prepared from horse serum. Trans-styrylthioacetic acid produced potent time-dependent inhibition of PHM. Potential mechanisms are proposed to explain PHM inactivation by unsaturated thioacetic acids.

Full text of DOI:10.1016/0960-894X(96)00041-8

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