Unsaturated thioacetic acids as novel mechanism-based inhibitors of peptidylglycine α-hydroxylating monooxygenase

DOI: 10.1016/0960-894X(96)00041-8

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 393 - 396 (1996)

Update date:2022-08-05

Topics:

Authors:

Casara Casara

Ganzhorn

Philippo

Chanal Chanal

Danzin Danzin

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/0960-894X(96)00041-8

Several unsaturated thioacetic acids were synthesized as potential mechanism-based inhibitors of peptidylglycine α-hydroxylating monooxygenase (PHM) prepared from horse serum. Trans-styrylthioacetic acid produced potent time-dependent inhibition of PHM. Potential mechanisms are proposed to explain PHM inactivation by unsaturated thioacetic acids.

Full text of DOI:10.1016/0960-894X(96)00041-8

Products guided by the article

Product name:(2-Hydroxy-2-phenyl-ethylsulfanyl)-acetic acid methyl ester

Cas No:175911-35-0

R&D Labs maybe for 175911-35-0

Puyang Willing Chemicals Co.,Ltd.

Contact:86-393-4840366

Address:Puyang Henan China
Hebei DaPeng Pharm & Chem Co., Ltd.

Contact:86-317-7298678,0576-88861898 88861908

Address:West Songmen Village, East Songmen Town, Wuqiao, Cangzhou, Hebei ,China
Jinzhou Jiutai Pharmaceutical Co.,Ltd

Contact:+86-0416-5179890

Address:No.41, Taianli, Taihe District, Jinzhou, Liaoning
Shanxi Sanwei Group Co.,Ltd

Contact:0086-357-6662688

Address:Zhaocheng town, Hongtong County, Linfen City, Shanxi Province
JIANGXI AIFEIMU TECHNOLOGY CO.，LTD

Contact:+86-570-6040289

Address:FINECHEMICAL PARK,ZIBU TOWN,WANNIAN COUNTY,JIANGXI PROV.,CHINA,ZIP

Relevant to this article

Enantioselective syntheses of (R)- and (S)-hexahydropyridazine-3-carboxylic acid derivatives

Doi:10.1055/s-1996-4192
(1996)
Synthesis of pyrrolizidine bases by highly diastereoselective and regioselective catalytic carbon-hydrogen insertion reactions of chiral pyrrolidinediazoacetamides

Doi:10.1016/0040-4039(96)00056-1
(1996)
Intramolecular acylations of γ-benzoyloxy phosphine oxides: Synthesis of optically active cyclopropyl ketones

Doi:10.1016/0040-4039(96)00049-4
(1996)
Inter- and intra-molecular selectivity in the cyclisation of N-cinnamoyl-1-naphthamides in solid-state photochemistry and peri selectivity in their photocyclisation in solution

Doi:10.1039/p19960000529
(1996)
New arylhexahydropyrimidinediones: Synthesis, benzodiazepine receptor affinity and anticonvulsant activity

Doi:10.1016/0223-5234(96)80371-0
(1996)
An R-selective hydroxynitrile lyase from Arabidopsis thaliana with an α/β-hydrolase fold

Doi:10.1002/anie.200701455
(2007)

Article Doi