Synthesis, Spectral, Thermal, and Biological Studies of Adducts of Organotin(IV) Halides with Schiff Bases Derived from 2-Amino-5-(o-methoxyphenyl)-1,3,4-thiadiazole

Article abstract of DOI:10.1246/bcsj.69.605

Some new organotin(IV) complexes of the general formula, R_nSnCl_4-n·L [where n = 3, R = CH₃ or C₆H₅: n = 2, R=C₆H₅; L= Schiff bases derived from the condensation of 2-amino-5-(o-methoxyphenyl)-1,3,4-thiadiazole with salicyl-aldehyde (L-1), 2-hydroxy-1-naphthaldehyde (L-2), 2′-hydroxyacetophenone (L-3), benzyl methyl ketone (L-4), acetylacetone (L-5), and 2-furancarbaldehyde (L-6)] have been synthesized and characterized by elemental analyses, molar conductances, electronic, infrared, far-infrared, ¹H and ¹¹⁹Sn NMR and Moessbauer spectral studies. Thermal studies of three complexes, viz., Ph₃SnCl(L-2), Me₃SnCl(L-4), and Ph₃SnCl(L-5) have been carried out in the temperature range 25-1000°C using TG, DTG, and DTA techniques. All these complexes decompose gradually with the formation of SnO₂ as an end product. In vitro antimicrobial activity of the ligands and their complexes has also been determined against Streptococcus faecalis, Kiebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus Penicillin resistance (2500 units), Candida albicans, Cryptococcus neoformans, Sporotrichum schenckii, Trichophyton mentagrophytes, and Aspergillus fumigatus.