A non-peptide photoactivatable antagonist for mapping the antagonist binding site of the tachykinin NK2 receptor

DOI: 10.1016/0960-894X(96)00075-3

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 605 - 608 (1996)

Update date:2022-09-26

Topics:

Authors:

Kersey Kersey

Bhogal Bhogal

Donnelly

Fishwick

Findlay Findlay

Ward Ward

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Article abstract of DOI:10.1016/0960-894X(96)00075-3

SR 48968, N-Methyl-N-[4-(4-acetamido-4-phenylpiperidinyl)-2S-(3,4-dichlorophenyl ) butyl]benzamide is a potent and selective non-peptidic antagonist of the NK₂ receptor. A photoactivatable analogue containing a diazirine moiety also binds with high affinity. This compound is potentially useful for identifying residues at the antagonist binding site of the NK₂ receptor.

Full text of DOI:10.1016/0960-894X(96)00075-3

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Product name:N-[2-(3,4-Dichloro-phenyl)-4-oxo-butyl]-N-methyl-3-(3-trifluoromethyl-3H-diazirin-3-yl)-benzamide

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