A non-peptide photoactivatable antagonist for mapping the antagonist binding site of the tachykinin NK2 receptor

DOI: 10.1016/0960-894X(96)00075-3

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 605 - 608 (1996)

Update date:2022-09-26

Topics:

Authors:

Kersey Kersey

Bhogal Bhogal

Donnelly

Fishwick

Findlay Findlay

Ward Ward

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/0960-894X(96)00075-3

SR 48968, N-Methyl-N-[4-(4-acetamido-4-phenylpiperidinyl)-2S-(3,4-dichlorophenyl ) butyl]benzamide is a potent and selective non-peptidic antagonist of the NK₂ receptor. A photoactivatable analogue containing a diazirine moiety also binds with high affinity. This compound is potentially useful for identifying residues at the antagonist binding site of the NK₂ receptor.

Full text of DOI:10.1016/0960-894X(96)00075-3

Products guided by the article

Product name:N-[2-(3,4-Dichloro-phenyl)-4-oxo-butyl]-N-methyl-3-(3-trifluoromethyl-3H-diazirin-3-yl)-benzamide

Cas No:176640-07-6

R&D Labs maybe for 176640-07-6

Taizhou Huading Chemical Co.,Ltd(expird)

Contact:+86-576-88583898

Address:Economic&Technology development zone,Taizhou City,Zhejiang Province,China
Oren Hydrocarbons (Qingdao) Co., Ltd.

Contact:+86-532-68607667-801

Address:Room 3 # 302, No.9 Qingyun Road, Qingdao, China
Frapp's Chemical (NFTZ) Co.,Ltd

Contact:+86-576-86137892

Address:General Chamber of Commercial Building, 159 Wanchang Middle Road, Wenling, Zhejiang, China
Changzhou naidechemical Co.Ltd

Contact:+86-519-82589807

Address:NO.25,Houyang street,Jintan,Changzhou City
Tianjin Jingye Fine Chemicals Co., Ltd.

Contact:+86-15722078107; +86-22-26911407

Address:Bohua Fine Chemicals Base of Petrochemical Industry Park, Nanhuan Road, Dagang District, Tianjin, 300271, P. R. China

Relevant to this article

Diastereoselective cyclopropanations of chiral bicyclic lactams leading to enantiomerically pure cyclopropanes. Application to the total synthesis of CIS-(1S, 3R)-deltamethrinic acid and R-(-)- dictyopterene C

Doi:10.1016/S0040-4020(01)85604-0
(1990)
Modified Bucherer-Bergs reaction for the one-pot synthesis of 5,5′-disubstituted hydantoins from nitriles and organometallic reagents

Doi:10.1055/s-2006-949644
(2006)
Doi:10.1021/ja01094a024
(1965)
Regioselective synthesis of 3-aryl substituted pyrrolidines via palladium catalyzed arylation: Pharmacological evaluation for central dopaminergic and serotonergic activity

Doi:10.1016/S0960-894X(96)00618-X
(1997)
Addition reactions of cyclic s-trans-enaminones with Grignard reagents

Doi:10.1016/S0040-4020(96)01133-7
(1997)
An effective synthesis of trifluoromethyl-substituted 1,4-dihydropyridines with phosphorus oxychloride / pyridine adsorbed on silica gel

Doi:10.1016/0040-4039(96)00788-5
(1996)

Article Doi