Novel syntheses of optically active CC-1065, U-73,975(adozelesin), U-80,244(carzelesin), U-77,779(bizelesin), KW-2189, and DU-86

Article abstract of DOI:10.3987/COM-97-7920

The title syntheses were achieved by the method featuring oxidative cyclization of the enamino esters [(S)-13 and (S)-24] derived from the 5-aminoindoline [(5)-12], acylation with various structural types of indole-2-carboxylic acids, and formation of cyclopropapyrroloindole moieties.