Journal of labelled compounds and radiopharmaceuticals p. 299 - 308 (1996)
Update date:2022-08-05
Topics:
Loustau-Then
Ponchant
Kamenka
Crouzel
The BTCP derivative 1-[1-(2-benzo(b)thiophenyl) cyclohexyl]-4-(2-hydroxyethyl) piperazine 2 showed, in vitro, high affinity and selectivity for the Dopamine transporter. In order to evaluate the potential of such a compound as an imaging tool for studying the dopaminergic system by Positron Emission Tomography (PET) the cold fluoroethyl BTCP piperazine 6, was synthesized. After checking the biological activity of the cold compound 6, the [18F] analogue 7 was synthesized. The radiosynthesis was carried out by the nucleophilic substitution of 1-[1-(2-benzo(b)thiophenyl) cyclohexyl]-4-(2-chloroethyl) piperazine 5 with cyclotron-produced n.c.a. 18F-, obtained by the (p,n) reaction on 18O enriched water.
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