Bioorganic and Medicinal Chemistry Letters p. 1171 - 1174 (1999)
Update date:2022-08-05
Topics:
Carter, Jeffery S.
Kramer, Steven
Talley, John J.
Penning, Thomas
Collins, Paul
Graneto, Matthew J.
Seibert, Karen
Koboldt, Carol M.
Masferrer, Jaime
Zweifel, Ben
A series of sulfonamide-substituted 4,5-diarylthiazoles was prepared via three synthetic routes as selective COX-2 inhibitors. Recently in the synthesis of selective COX-2 inhibitors we have discovered that the sulfonamide moiety is a suitable replacement
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