Synthesis and activity of sulfonamide-substituted 4,5-diaryl thiazoles as selective cyclooxygenase-2 inhibitors

DOI: 10.1016/S0960-894X(99)00157-2

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1171 - 1174 (1999)

Update date:2022-08-05

Topics:

Authors:

Carter, Jeffery S.

Kramer, Steven

Talley, John J.

Penning, Thomas

Collins, Paul

Graneto, Matthew J.

Seibert, Karen

Koboldt, Carol M.

Masferrer, Jaime

Zweifel, Ben

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(99)00157-2

A series of sulfonamide-substituted 4,5-diarylthiazoles was prepared via three synthetic routes as selective COX-2 inhibitors. Recently in the synthesis of selective COX-2 inhibitors we have discovered that the sulfonamide moiety is a suitable replacement

Full text of DOI:10.1016/S0960-894X(99)00157-2

Products guided by the article

Product name:4-[5-(4-bromo-phenyl)-2-methyl-thiazol-4-yl]-benzenesulfonamide

Cas No:177560-66-6

R&D Labs maybe for 177560-66-6

Antaeus Bio-technology Co., LTD(expird)

Contact:021-31252569

Address:shanghai pudong
Jiangsu Mingchem Corporation

website:http://www.mingchem.com/en/index

Contact:0519-85170101-802

Address:Fifth Floor,B of Beihua Buliding,520 Road of Science and Education City,Changwu middle road NO.801,Wujin District,Changzhou,Jiangsu province
HANGZHOU ZHONGCHANG SCIENTIFIC CO.,LTD

Contact:+86-571-88932183

Address:Hangzhou
Jining Shengrun Chemical Industry Co., Ltd.

Contact:+86-537-7121666 ,

Address:West Ring Road,Wenshang County Shandong Province
Beijing ZhongDaXinHe Chemical Product Co.,Ltd(expird)

Contact:010-52876516

Address:tongzhoubeiyuan

Relevant to this article

Doi:10.1021/ja01597a062
(1956)
Addition of bromotrichloromethane and tetrachloromethane to cis-cyclooctene, cyclohexene, and norbornadiene in the presence of palladium(II) complexes

Doi:10.1023/B:RUJO.0000003181.02370.cf
(2003)
Insertion of an aspartic acid moiety into cyclic pseudopeptides: Synthesis and biological characterization of potent antagonists for the human tachykinin NK-2 receptor

Doi:10.1021/jm040832y
(2004)
Hydrogenolysis of the 4,6-o-ketals of glucopyranosides. Configuration-dependent high regio- and stereo-selectivity of the diastereoisomeric acetophenone derivatives

Doi:10.1071/CH9960357
(1996)
Design, synthesis, and biological evaluation of novel substituted thiourea derivatives as potential anticancer agents for NSCLC by blocking K-Ras protein-effectors interactions

Doi:10.1080/14756366.2019.1702653
(2020)
Reactions of dinuclear and polynuclear complexes XVI. Chemistry of hydrido-, thiolato-bridged complexes [Mo₂Cp₂(μ-H)(μ-SR)(CO)₄](R = Me, Ph): Reactivity and electrochemical behaviour; crystal structure of [Mo₂Cp₂(μ-SPh) {μ-σ:η²-C(CH₃) =CHCH₃}(CO)₂]¹

Doi:10.1016/0022-328X(95)05902-2
(1996)

Article Doi