Synthesis and activity of sulfonamide-substituted 4,5-diaryl thiazoles as selective cyclooxygenase-2 inhibitors

DOI: 10.1016/S0960-894X(99)00157-2

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1171 - 1174 (1999)

Update date:2022-08-05

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Authors:

Carter, Jeffery S.

Kramer, Steven

Talley, John J.

Penning, Thomas

Collins, Paul

Graneto, Matthew J.

Seibert, Karen

Koboldt, Carol M.

Masferrer, Jaime

Zweifel, Ben

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Article abstract of DOI:10.1016/S0960-894X(99)00157-2

A series of sulfonamide-substituted 4,5-diarylthiazoles was prepared via three synthetic routes as selective COX-2 inhibitors. Recently in the synthesis of selective COX-2 inhibitors we have discovered that the sulfonamide moiety is a suitable replacement

Full text of DOI:10.1016/S0960-894X(99)00157-2

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