A novel synthesis of piperidin-3-ones via an intramolecular Amadori-type reaction

Article abstract of DOI:10.1016/0040-4039(96)00499-6

1-Methoxycarbonyl-2-(3,5-dimethoxy-4-benzyloxyphenyl)-piperidin-3 one 1 and rac-5R, 8aS-5-(3,5-dimethoxy-4-t-butyldimethylsiloxyphenyl)-oxazolo[3,4:1,6]-p iperidin-3,6-dione 2 were synthesized via an intramolecular adaptation of the biochemically well-characterized Amadori reaction.