A novel synthesis of 3-aryl-5-tert-butyl-4-oxazolin-2-ones

DOI: 10.1248/cpb.44.699

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 699 - 702 (1996)

Update date:2022-08-04

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Authors:

Kudo, Noriaki

Taniguchi, Misa

Sato, Kazuo

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Article abstract of DOI:10.1248/cpb.44.699

An efficient synthetic method for 3-aryl-5-tert-butyl-4-oxazolin-2-ones (6) is described. The reaction of ethyl N-arylcarbamates (10) with 1-bromo- 3,3-dimethyl-2-butanone (9a) or 1-bromo-3-ethyl-3-methyl-2-pentanone (9b) using 2.2 eq of lithium his(trime

Full text of DOI:10.1248/cpb.44.699

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