Dopaminergic benzo[a]phenanthridines: Resolution and pharmacological evaluation of the enantiomers of dihydrexidine, the full efficacy D1 dopamine receptor agonist

DOI: 10.1021/jm00041a025

Source and publish data:

Journal of Medicinal Chemistry p. 2453 - 2460 (1994)

Update date:2022-08-03

Topics:

Authors:

Knoerzer

Nichols Nichols

Brewster

Watts Watts

Mottola Mottola

Mailman Mailman

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00041a025

Racemic trans-10,11-dihydroxy-5,6,6a,7,8,12b- hexahydrobenzo[a]phenanthridine (2, dihydrexidine) was shown previously to be the first bioavailable full efficacy agonist at the D₁ dopamine receptor. In addition to its full D₁ agonist

Full text of DOI:10.1021/jm00041a025

Products guided by the article

Product name:(6aR,12bS)-(+)-6-((R)-α-methoxyphenylacetyl)-10,11-dimethoxy-5,6,6a,7,8,12b-hexahydrobenzo phenanthridine

Cas No:177470-32-5

R&D Labs maybe for 177470-32-5

Qingdao XinYongAn Chemicals Co., Ltd

Contact:+86-532-81107967

Address:Chengyang dual-port industrial park by the sea，Qingdao
Borun Chemical Co.,Ltd.

Contact:+86-574- 87178138; 87297407

Address:No. 809, Liudingxingzuo, cangsong road, Ningbo, China
Weifang Jahwa Chemical Co.,Ltd

Contact:0086-536-8897731,8897730

Address:No.5166 East Dongfeng Street,Weifang,Shandong,China
Yicheng Goto Pharmaceuticals Co.,Ltd.

Contact:+86 710 3423122

Address:5th Floor,East Gate of Building #2,Servo-Industrial Park,1st Qilin Road,Xiangyang,Hubei,China
Jitat Company Ltd

Contact:852-27701081

Address:Room 2509, New Tech Plaza, 34 Tai Yau St., San Po Kong, HK

Relevant to this article

Doi:10.1002/hlca.19640470753
(1964)
Exploration of 3-aminoazetidines as triple reuptake inhibitors by bioisosteric modification of 3-α-Oxyazetidine

Doi:10.1021/ml500187a
(2014)
XBphos-Rh: A halogen-bond assembled supramolecular catalyst

Doi:10.1039/c8sc00233a
(2018)
Rhodium-catalyzed asymmetric 1,4-addition of organoboron reagents to 5,6-dihydro-2(1H)-pyridinones. Asymmetric synthesis of 4-aryl-2-piperidinones

Doi:10.1021/jo0103930
(2001)
Gallium(III) catecholate complexes as probes for the kinetics and mechanism of inversion and isomerization of siderophore complexes

Doi:10.1021/ja953545f
(1996)
A novel synthesis of 2,5-dihydropyrrole derivatives as enantiomerically enriched building blocks

Doi:10.1016/0040-4020(96)00323-7
(1996)

Article Doi