Dopaminergic benzo[a]phenanthridines: Resolution and pharmacological evaluation of the enantiomers of dihydrexidine, the full efficacy D1 dopamine receptor agonist

DOI: 10.1021/jm00041a025

Source and publish data:

Journal of Medicinal Chemistry p. 2453 - 2460 (1994)

Update date:2022-08-03

Topics:

Authors:

Knoerzer

Nichols Nichols

Brewster

Watts Watts

Mottola Mottola

Mailman Mailman

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Article abstract of DOI:10.1021/jm00041a025

Racemic trans-10,11-dihydroxy-5,6,6a,7,8,12b- hexahydrobenzo[a]phenanthridine (2, dihydrexidine) was shown previously to be the first bioavailable full efficacy agonist at the D₁ dopamine receptor. In addition to its full D₁ agonist

Full text of DOI:10.1021/jm00041a025

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Product name:(6aR,12bS)-(+)-6-((R)-α-methoxyphenylacetyl)-10,11-dimethoxy-5,6,6a,7,8,12b-hexahydrobenzo phenanthridine

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