An intramolecular 1,3-dipolar cycloaddition approach to a pyrimidoazepinone derivative. A potentially useful intermediate towards the synthesis of pyrimidoazepine based folic acid derivatives

Article abstract of DOI:10.1016/0040-4020(96)00232-3

An intramolecular nitrile oxide cycloaddition route to the isoxazolinopyrimidoazepine derivative 21 is described. This was transformed to the pyrimidoazepinone derivative 22, a potentially useful intermediate for the synthesis of pyrimidoazepine based fol