Bioorganic and Medicinal Chemistry Letters p. 3443 - 3448 (1998)
Update date:2022-07-30
Topics:
Barta, Thomas E.
Stealey, Michael A.
Collins, Paul W.
Weier, Richard M.
The synthesis and activity of a series of 4,5-diarylimidazole analogs are described. One analog had an IC50 of 80 nM, was 6750-selective against COX-1, and demonstrated in vivo potency in the mouse air pouch model.
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