Chemical and Pharmaceutical Bulletin p. 297 - 304 (1997)
Update date:2022-07-30
Topics:
Kotani, Takayuki
Ishii, Akira
Nagaki, Yasuhiro
Toyomaki, Yoshio
Yago, Hisashi
Suehiro, Seishi
Okukado, Nobuhisa
Okamoto, Kaoru
Accumulation of intracellular sorbitol, the product of glucose reduction catalyzed by aldose reductase (AR) [EC 1.1.1.21], is thought to be the main culprit in the development of diabetic complications. A series of 3- arylalkyl-2,4,5-trioxoimidazolidine-1-acetic acids was prepared and tested for inhibitory activities towards AR and aldehyde reductase (ALR) [EC 1.1.1.2]. These derivatives showed strong inhibitory activity against AR without markedly inhibiting ALR. In particular, the compounds with 3- nitrophenyl, 4-chloro-3-nitrophenyl, and chloro-substituted benzothiazolyl groups as the aryl part showed powerful AR-inhibitory activity. The chloro- substituted benzothiazolyl compound showed an AR selectivity of more than 5000 fold.
View MoreTaizhou Elitechemie MediPharma Technology Co.,Ltd.
Contact:+86-523-86810021
Address:Building G14,NO.1 Avenue,China Medical City, Taizhou, Jiangsu,China
zhengzhou Triz Pharma-Tech Co., Ltd
website:http://www.Trizpharma-tech.com
Contact:+86-0371-86597269，53392065
Address:High-tech Industrial Development Zone, Zhengzhou City, NO.7 Holly Street
Wuxi Zuping Food Science And Technology Co.,LTD.
Contact:+86-510-87210822
Address:Guanlin town
Contact:+86-518-81061113
Address:No. 8 Lingzhou Road, Lianyungang, Jiangsu, China
Shandong General Materials Co.,Ltd（Shandong Aoertong Chemical Co., Ltd）
Contact:86-531-88072280
Address:No. 1825 Hualong Road, Licheng District, Jinan, Shandong, China
Doi:10.1039/p19960001205
(1996)Doi:10.1002/cber.19681010306
(1968)Doi:10.1021/jm980190c
(1998)Doi:10.1016/j.tetlet.2011.08.151
(2011)Doi:10.1248/cpb.40.1789
(1992)Doi:10.1016/0040-4039(96)00842-8
(1996)
