Bioorganic and Medicinal Chemistry Letters p. 1985 - 1990 (1998)
Update date:2022-08-03
Topics:
Valli, Matthew J.
Schoepp, Darryle D.
Wright, Rebecca A.
Johnson, Bryan G.
Kingston, Ann E.
Tomlinson, Rosemarie
Monn, James A.
A series of N1-substituted derivatives of (2R,4R)-4-aminopyrrolidine- 2,4-dicarboxylate (2R,4R-APDC) has been prepared as constrained analogs of γ-substituted glutamic acids and examined for their effects at recombinant metabotropic glutamate receptor (mGluR) subtypes in vitro. Appropriate substitution of the N1 position of 2R,4R-APDC resulted in the identification of a number of selective group II mGluR antagonists.
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