Tetrahedron Letters p. 6515 - 6518 (1996)
Update date:2022-08-03
Topics:
Wang, Guangyi
Seifert, Wilfried E.
4'-C-Hydroxymethylthymidine was converted to 4'-C-methoxymethylthymidine and 4'-C-aminomethylthymidine, which were incorporated into oligodeoxynucleotides by phosphoramidite chemistry. The modified oligonucleotides exhibit excellent hybridization and significant improvement in stability to snake venom phosphodiesterase.
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