Bioorganic and Medicinal Chemistry Letters p. 1029 - 1034 (1996)
Update date:2022-08-05
Topics:
Kinder Jr., Frederick R.
Wang, Run-Ming
Bauta, William E.
Bair, Kenneth W.
Novel bicyclic and isomeric analogues of the cytotoxic sesquiterpine illudin M were prepared using 1,3-dipolar cycloaddition reactions. Nearly every analogue investigated demonstrated low μM IC50 values when tested in a panel of four human tumor cell lines.
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