Application of the sulfonamide functional groups as an anchor for solid phase organic synthesis (SPOS)

Article abstract of DOI:10.1016/0040-4039(95)02418-2

Sulfonyl chlorides have been found to readily couple to an amino functionalized resin. The resulting sulfonamide anchoring group is stable to a variety of reactions commonly used in SPOS. Acid induced cleavage is facile, affording functionalized sulfonamides in high yields.