Application of the sulfonamide functional groups as an anchor for solid phase organic synthesis (SPOS)

DOI: 10.1016/0040-4039(95)02418-2

Source and publish data:

Tetrahedron Letters p. 1145 - 1148 (1996)

Update date:2022-08-03

Topics:

Authors:

Beaver Beaver

Siegmund

Spear Spear

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Article abstract of DOI:10.1016/0040-4039(95)02418-2

Sulfonyl chlorides have been found to readily couple to an amino functionalized resin. The resulting sulfonamide anchoring group is stable to a variety of reactions commonly used in SPOS. Acid induced cleavage is facile, affording functionalized sulfonamides in high yields.

Full text of DOI:10.1016/0040-4039(95)02418-2

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