New procedures for the synthesis of heterocyclic substituted and 2,4-difunctionalized pyrimidines

Article abstract of DOI:10.1016/0040-4020(96)00368-7

N-Tosyl-2-and -3-acetylpyrrols 1 or N-tosyl-2-pyrrolidone 5 were condensed with cyano compounds in the presence of triflic anhydride (Tf₂O) to yield heteroarylpyrimidines. 2,4-Difunctionalized pyrimidines were obtained by reaction of the corresponding 2,4-bis(methylsulfonyl)pyrimidines with nucleophiles.