New neplanocin analogues. V. A potent adenosylhomocysteine hydrolase inhibitor lacking antiviral activity. Synthesis and antiviral activity of 6′-carboxylic acid derivatives of neplanocin A

Article abstract of DOI:10.1080/07328319608007384

The 6′-carboxylic acid derivative of neplanocin A 3 was synthesized from NPA, and was converted to the corresponding methyl ester 4 and amides 5 and 6. These were evaluated for their anti-RNA-virus activities. Of the derivatives synthesized, only 5 was ac

Full text of DOI:10.1080/07328319608007384

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New Neplanocin Analogues. V.
A Potent Adenosylhomocysteine
Hydrolase Inhibitor Lacking Antiviral
Activity. Synthesis And Antiviral
Activity Of 6″-Carboxylic Acid
Derivatives Of Neplanocin A
Takumi OBARA a , Satoshi SHUUTO b , Yasuyoshi SAITO a , Minoru
TORIYA a , Kiyoshi OGAWA a , Satoshi YAGINUMA a , Shiro SHIGETA
c & Akira MATSUDA a b
a Institute for Life Science Research, Asahi Chemical Industry
Co., Ltd. , Mifuku, Ohito-cho, Shizuoka, 410-23, Japan
b Faculty of Pharmaceutical Science , Hokkaido University ,
Kita-12, Nishi-6, Kita-ku, Sapporo, 060, Japan
c Department of Microbiology , Fukushima Medical College ,
Fukushima, 960-12, Japan
Published online: 19 Aug 2006.
To cite this article: Takumi OBARA , Satoshi SHUUTO , Yasuyoshi SAITO , Minoru TORIYA , Kiyoshi
OGAWA , Satoshi YAGINUMA , Shiro SHIGETA & Akira MATSUDA (1996) New Neplanocin Analogues.
V. A Potent Adenosylhomocysteine Hydrolase Inhibitor Lacking Antiviral Activity. Synthesis
And Antiviral Activity Of 6″-Carboxylic Acid Derivatives Of Neplanocin A , Nucleosides and
Nucleotides, 15:6, 1157-1167, DOI: 10.1080/07328319608007384
To link to this article: http://dx.doi.org/10.1080/07328319608007384
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