A selective procedure for α-alkenylation of enones involving Pd-catalyzed alkenyl-alkenyl coupling and its application to a convergent and efficient synthesis of nakienone B

Article abstract of DOI:10.1016/0040-4039(96)00962-8

A convergent and efficient synthesis of a marine natural product, nakienone B (1), was achieved using a new protocol for α-alkenylation of enones involving Pd-catalyzed coupling of alkenylzincs with alkenyl iodides. This protocol features (i) avoidance of acidic conditions and (ii) flexibility in charge affinity pattern with respect to the two alkenyl groups to be coupled.