Carboxylated α-pyrone derivatives and flavonoids from the liverwort Dumortiera hirsuta

Article abstract of DOI:10.1016/0031-9422(96)00242-7

Three new carboxylated α-pyrone derivatives, dumortins A-C, and a new flavone glycoside have been isolated from the liverwort, Dumortiera hirsuta, together with the known flavonoids, luteolin, luteolin-5-O-β-D-glucuronide and luteolin-7-O-β-D-glucuronide. The structures of the new α-pyrones were confirmed spectroscopically as 4-(3',4'-dihydroxy-E-styryl)-6-carboxy-α- pyrone,4-[2-(3',4'-dihydroxyphenyl)-ethyl]-6-carboxy-α-pyrone and 3-[1- hydroxy-2-(3',4'-dihydroxyphenyl)-ethyl]-6-carboxy-α-pyrone. The new flavonoid was elucidated as luteolin-5-O-β-D-glucuronide-6'-methyl ester. The structures of dumortins A and B were confirmed by independent chemical synthesis.