Stereocontrolled synthesis of chiral secondary (α-methylene-β-substituted)-γ-lactams by addition of β-functional crotylzinc reagents to chiral imines

Article abstract of DOI:10.1016/0957-4166(96)00219-4

Stereocontrolled addition of functionalised crotylzinc reagents to chiral imines derived either from N-α-aminoesters or N-β-aminoalcohols furnished secondary α-methylene-β-substituted-γ-lactams in excellent diastereoisomeric excess (de ≈ 92-100%). Copyrig