Stereocontrolled synthesis of chiral secondary (α-methylene-β-substituted)-γ-lactams by addition of β-functional crotylzinc reagents to chiral imines

DOI: 10.1016/0957-4166(96)00219-4

Source and publish data:

Tetrahedron Asymmetry p. 1835 - 1843 (1996)

Update date:2022-08-03

Topics:

Authors:

Nyzam, Valerie

Belaud, Chantal

Zammattio, Francoise

Villieras, Jean

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Article abstract of DOI:10.1016/0957-4166(96)00219-4

Stereocontrolled addition of functionalised crotylzinc reagents to chiral imines derived either from N-α-aminoesters or N-β-aminoalcohols furnished secondary α-methylene-β-substituted-γ-lactams in excellent diastereoisomeric excess (de ≈ 92-100%). Copyrig

Full text of DOI:10.1016/0957-4166(96)00219-4

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