Stereocontrolled synthesis of chiral secondary (α-methylene-β-substituted)-γ-lactams by addition of β-functional crotylzinc reagents to chiral imines

DOI: 10.1016/0957-4166(96)00219-4

Source and publish data:

Tetrahedron Asymmetry p. 1835 - 1843 (1996)

Update date:2022-08-03

Topics:

Authors:

Nyzam, Valerie

Belaud, Chantal

Zammattio, Francoise

Villieras, Jean

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/0957-4166(96)00219-4

Stereocontrolled addition of functionalised crotylzinc reagents to chiral imines derived either from N-α-aminoesters or N-β-aminoalcohols furnished secondary α-methylene-β-substituted-γ-lactams in excellent diastereoisomeric excess (de ≈ 92-100%). Copyrig

Full text of DOI:10.1016/0957-4166(96)00219-4

Products guided by the article

Product name:ethyl (3-methylene-4(R)-methyl-5(R)-phenylpyrrolidinone-1-yl)-2(R)-phenylacetate

Cas No:180128-63-6

R&D Labs maybe for 180128-63-6

Baoding City Light Industry And Textiles Imp.& Exp. Corp. Chemical Department.

Contact:86-312-3262436

Address:NO.658 CHAOYANG SOUTH STREET,BAODING CITY HEBEI CHINA
Xinchang Yueding Chemical Co., Ltd.

Contact:86-571-56926323

Address:NO.90 BEIMENCHENGWAI CHENGGUAN TOWN XINCHANG
Hangzhou Yanshan Chemical Co.,Ltd.

Contact:86-571- 87698076

Address:Room 1001, #1 Building, Zhongtian MCC, No.2 Youzhinong, Wenyi West Road, Xihu District, Hangzhou, China
Antaeus Bio-technology Co., LTD(expird)

Contact:021-31252569

Address:shanghai pudong
Shandong Jincheng Zhonghua Bio-pharmaceutical Co.,Ltd

Contact:+86-533-5415882

Address:Zichuan Economic Development Zone,Zibo City,Shandong Province,China

Relevant to this article

Synthesis and crystal structure of novel 1,3-heterobinuclear complexes with an unusual cyclic C₄R₃ bridging ligand

Doi:10.1021/om960278t
(1996)
Drug Design Inspired by Nature: Crystallographic Detection of an Auto-Tailored Protease Inhibitor Template

Doi:10.1002/anie.201812348
(2019)
A New Access to Piperidino-cyclopiperidinecarboxamides - Constrained Analogues of a Pharmaceutical used Diaminic Building Block

Doi:10.1002/prac.19963380190
(1996)
Transition-metal-free one-pot synthesis of alkynyl selenides from terminal alkynes under aerobic and sustainable conditions

Doi:10.3762/bjoc.13.92
(2017)
Synthesis and Structure-Activity Studies of a Series of <(Hydroxybenzyl)amino>salicylates as Inhibitors of EGF Receptor-Associated Tyrosine Kinase Activity

Doi:10.1021/jm00077a014
(1993)
Synthesis of 3-(1-arylaminocarbonyl-5-amino)-1,2,4-triazolyl benzyl sulfide, sulfoxide and sulfone

Doi:10.1080/10426509608029653
(1996)

Article Doi