Synthesis and pharmacological study of some adamantylcyclopentanamines

Article abstract of DOI:10.1016/0223-5234(91)90154-F

In this paper the synthesis of adamantylcyclopentanamines 5, 7 and 8 is described. The experimental data obtained with these derivatives on mice (behaviour, effect on the reserpinic catalepsy or hypothermy, study of the convulsions obtained with high doses) argue in favour of the existence of a glutamatergic component on the action mechanism of these adamantanamines.