A novel regio- and stereoselective synthesis of isoindolines

DOI: 10.1016/0040-4039(96)01018-0

Source and publish data:

Tetrahedron Letters p. 5065 - 5068 (1996)

Update date:2022-07-30

Topics:

Authors:

Kukkola, Paivi J.

Bilci, Natalie A.

Ikeler, Theodore J.

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Article abstract of DOI:10.1016/0040-4039(96)01018-0

The described synthesis of isomeric isoindoline dicarboxylic acid analogs 1 and 2, two potent ETA selective receptor antagonists, involves an efficient regioselective route to highly functionalized dibenzoylbenzenes and a novel methodology for the stereoselective preparation of trans and cis 1,3- disubstituted isoindolines.

Full text of DOI:10.1016/0040-4039(96)01018-0

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