Bioorganic and Medicinal Chemistry Letters p. 1553 - 1558 (1996)
Update date:2022-08-03
Topics:
Pop, Emil
Browne, Clinton E.
Nadler, Varda
Biegon, Anat
Brewster, Marcus E.
The synthesis and evaluation of two novel cannabinoids belonging to the (+) 3S, 4S nonpsychotropic series are described. These derivatives bind to the NMDA receptor but have lower affinities than dexanabinol (HU-211), the series benchmark. The novel compounds protect neurons against MDA- induced toxicity in cortical cell cultures and have lower toxicity to host neurons than dexanabinol.
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Doi:10.1016/0968-0896(96)00075-2
(1996)Doi:10.1016/S0957-4166(98)00246-8
(1998)Doi:10.1016/0040-4039(96)00934-3
(1996)Doi:10.1016/0277-5387(96)00080-0
(1996)Doi:10.1016/j.chemphyslip.2006.09.002
(2006)Doi:10.1246/cl.1996.811
(1996)
