Bioorganic and Medicinal Chemistry Letters p. 1563 - 1566 (1996)
Update date:2022-08-03
Topics:
Hutchinson, Ian
Archer, Sydney
Hill, Kevin P.
Bidlack, Jean M.
14β-2-chloroacrylamido-7,8-dihydromorphinones 7 and 8 and the corresponding 6β-7,8-dihydromorphinans 19 and 20 were prepared and the binding affinities to μ, δ and κ receptors in bovine striatal membranes were determined. Only 20 produced wash-resistant inhibition of m binding despite the fact that it formed adducts with N-acetylcysteine at pH 10 and not at pH 8.
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