Cyclohexenone construction by intramolecular alkylidene C-H insertion: Synthesis of (+)-cassiol

Article abstract of DOI:10.1021/jo960973a

We report new procedures for stereoselective cyclopentene and cyclohexenone construction employing the alkylidene carbene C-H insertion reaction. Described are diastereoselective insertion into methylene and enantiospecific insertion into methine C-H bonds. The latter case leads directly to the enantioselective synthesis of (+)-cassiol (1).