Concise synthesis of α-alkyl α-amino acids and their incorporation into peptides via β-lactam-derived α-amino acid N-carboxy anhydrides

Article abstract of DOI:10.1039/CC9960001269

a-Hydroxy β-lactams in which C₄ exists as a quaternary carbon are transformed in a single one-pot operation into α,α-dialkyl α-amino acid N-carboxy anhydrides providing a new approach to conformationally restricted peptide segments from non α-a

Full text of DOI:10.1039/CC9960001269

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