Concise synthesis of α-alkyl α-amino acids and their incorporation into peptides via β-lactam-derived α-amino acid N-carboxy anhydrides

DOI: 10.1039/CC9960001269

Source and publish data:

Chemical Communications p. 1269 - 1270 (1996)

Update date:2022-08-02

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Authors:

Palomo, Claudio

Aizpurua

Ganboa, Inaki

Odriozola, Beatriz

Urchegui, Raquel

Goerls, Helmar

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Article abstract of DOI:10.1039/CC9960001269

a-Hydroxy β-lactams in which C₄ exists as a quaternary carbon are transformed in a single one-pot operation into α,α-dialkyl α-amino acid N-carboxy anhydrides providing a new approach to conformationally restricted peptide segments from non α-a

Full text of DOI:10.1039/CC9960001269

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