Synthesis and biological evaluation of N-(1-aziridino)-6-fluoro- quinolone-3-carboxylic acids

DOI: 10.1016/S0960-894X(96)00259-4

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1507 - 1510 (1996)

Update date:2022-07-29

Topics:

Authors:

Batori, Sandor

Timari, Geza

Koczka, Istvan

Hermecz, Istvan

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(96)00259-4

New racemic N-(1-aziridino)-6-flouro-7-(4-methylpiperazin-1-yl)-4(1H)- quinolone-3-carboxylic acids (9a-i) were synthesized and their antibacterial activities were tested against Gram-positive and Gram-negative micro- organisms. According to the MIC, all compounds studied are less active than Ciprofloxacin; two of them (9a,b) have similar activity as Nalidixic acid (1).

Full text of DOI:10.1016/S0960-894X(96)00259-4

Products guided by the article

Product name:6-Fluoro-7-(4-methyl-piperazin-1-yl)-4-oxo-1-(2-phenyl-aziridin-1-yl)-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester

Cas No:181426-78-8

R&D Labs maybe for 181426-78-8

Wuxi Olite Chemical Co., Ltd.

Contact:86-510-82853889

Address:Rm.3732, No.18-2,Yonghe Rd.,Wuxi,Jiangsu,214023,China
Sdow

website:http://www.sdowchem.com

Contact:86-135-2193 7483

Address:8-106 taiyue building
Zhejiang Sanmei Chemical Industry Co., Ltd

Contact:86-579-87633213

Address:Huchu Industrial Zone, Qingnian Rd., Wuyi County, Zhejiang Prov., China.
LinHai Cina Chemical Co., LTD.

Contact:0576-85580989

Address:Pharma-chem zone,Duqiao,Linhai,Zhejiang,China
Chiral Quest (Suzhou) Company Ltd

website:http://www.chiralquest.com

Contact:+86-0512-62956066

Address:B1/9, 218 Xinghu Street, Suzhou Industrial Park

Relevant to this article

2-substituted-(2SR)-2-amino-2-((1SR,2SR)-2-carboxycycloprop-1- yl)glycines as potent and selective antagonists of group II metabotropic glutamate receptors. 1. Effects of alkyl, arylalkyl, and diarylalkyl substitution

Doi:10.1021/jm970497w
(1998)
Preparation and enantiomer recognition behaviour of azophenolic crown ethers containing cis-1-phenylcyclohexane-1,2-diol as the chiral subunit and 2,4-dinitrophenylazophenol as the chromophore

Doi:10.1039/p19960000383
(1996)
RITA Mimics: Synthesis and Mechanistic Evaluation of Asymmetric Linked Trithiazoles

Doi:10.1021/acsmedchemlett.6b00488
(2017)
Efficient asymmetric synthesis of the four diastereomers of diphenacoum and brodifacoum

Doi:10.1016/S0040-4020(97)00254-8
(1997)
Synthesis and antitumor activity of duocarmycin derivatives: A-Ring pyrrole analogues of duocarmycin B2

Doi:10.1016/0968-0896(96)00132-0
(1996)
Doi:10.1021/ja01192a049
(1948)

Article Doi