Synthesis and biological evaluation of N-(1-aziridino)-6-fluoro- quinolone-3-carboxylic acids

DOI: 10.1016/S0960-894X(96)00259-4

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1507 - 1510 (1996)

Update date:2022-07-29

Topics:

Authors:

Batori, Sandor

Timari, Geza

Koczka, Istvan

Hermecz, Istvan

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Article abstract of DOI:10.1016/S0960-894X(96)00259-4

New racemic N-(1-aziridino)-6-flouro-7-(4-methylpiperazin-1-yl)-4(1H)- quinolone-3-carboxylic acids (9a-i) were synthesized and their antibacterial activities were tested against Gram-positive and Gram-negative micro- organisms. According to the MIC, all compounds studied are less active than Ciprofloxacin; two of them (9a,b) have similar activity as Nalidixic acid (1).

Full text of DOI:10.1016/S0960-894X(96)00259-4

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Product name:6-Fluoro-7-(4-methyl-piperazin-1-yl)-4-oxo-1-(2-phenyl-aziridin-1-yl)-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester

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