Bioorganic and Medicinal Chemistry Letters p. 1525 - 1528 (1996)
Update date:2022-08-05
Topics:
Bannwarth, Willi
Huebscher, Josef
Barner, Richard
We describe a new linker molecule (ADCC-linker) for the attachment of primary amines to solid support. The linker is stable towards acidic conditions (eg. TFA) basic conditions (eg. piperidine, DBU) as well as towards uronium type coupling reagents. The amine can be quantitatively released from the support using a 2% hydrazine in DMF solution.
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