A new linker for primary amines applicable to combinatorial approaches

DOI: 10.1016/S0960-894X(96)00258-2

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1525 - 1528 (1996)

Update date:2022-08-05

Topics:

Authors:

Bannwarth, Willi

Huebscher, Josef

Barner, Richard

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Article abstract of DOI:10.1016/S0960-894X(96)00258-2

We describe a new linker molecule (ADCC-linker) for the attachment of primary amines to solid support. The linker is stable towards acidic conditions (eg. TFA) basic conditions (eg. piperidine, DBU) as well as towards uronium type coupling reagents. The amine can be quantitatively released from the support using a 2% hydrazine in DMF solution.

Full text of DOI:10.1016/S0960-894X(96)00258-2

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