A study of 3-amino-N-hydroxypropanesulfonamide derivatives as potential GABA(B) agonists and their fragmentation to 3-aminopropanesulfinic acid

DOI: 10.1016/0960-894X(96)00307-1

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1709 - 1714 (1996)

Update date:2022-08-04

Topics:

Authors:

Shue, Ho-Jane

Chen, Xiao

Blythin, David J.

Carruthers, Nicholas I.

Spitler, James M.

Wong, Shing-Chun

Chapman, Richard W.

Rizzo, Charles

West, Robert

She, Hoyan S.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/0960-894X(96)00307-1

A series of 3-amino-N-hydroxypropanesulfonamide analogs were prepared. Several compounds showed potent binding at the GABA(B) receptor and were active in an in vitro functional assay. The GABA(B) activity of these compounds appeared to be due to the fragmented product, 3-aminopropanesulfinic acid.

Full text of DOI:10.1016/0960-894X(96)00307-1

Products guided by the article

Product name:3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-propane-1-sulfonic acid benzyloxy-amide

Cas No:181510-07-6

R&D Labs maybe for 181510-07-6

Afine Chemicals Limited

website:http://www.afinechem.com

Contact:+86-571-85134551

Address:No. 206 Zhen Hua Road, Hangzhou 310030, Zhejiang, China
chemonlinephramacistdepot

Contact:86-607-68073220

Address:1 ave na road jiahua st
Shanghai Surseechem Co.,Ltd.

Contact:+86-21-61318535

Address:Building 29,No.2139 Xizha Road, Fengxian District, Shanghai
Changsha Kamer Essence and Flavor Co.,Ltd

Contact:86-731-89832270

Address:No.327 Kangnin Road Changsha Bio Information Industry Park, Changsha city, Hunan province
A.M FOOD CHEMICAL CO., LIMITED

Contact:86-531-87100375

Address:20Floor，Bblock，1Building，pharma-valley，Jinan，China

Relevant to this article

Homogeneous hydrogenation with new cationic ruthenium(II) complexes of [RuH(CO)(NCCH₃)(PPh₃)₂(diphos)]⁺ and [RuH(CO)(NCCH₃)(PPh₃)(diphos)]⁺. Crystal structure of [RuH(CO)(NCCH₃)(PPh₃) (Fe(η⁵-C₅H₄PPh₂) ₂)][BF₄]

Doi:10.1016/0277-5387(96)00103-9
(1996)
Reactions of (σ-alkynyl)platinum complexes with [Pd(η³-C₃H₅)Cl]₂. Synthesis of bis(η²-alkyne)(η³-allyl)palladiuin(II) complexes. Crystal and molecular structure

Doi:10.1021/om9603326
(1996)
Synthesis and electrospray mass spectrometry of platinum(ii) complexes derived from thiourea dianions and the x-ray structure of [pt{nmec(=ncn)s}(cod)] (cod = cyclo-octa-1,5-diene)

Doi:10.1016/0277-5387(96)00133-7
(1996)
Inner sphere complexes derived from the coordinate interactions of tin(IV) isothiocyanate moieties with 1-[(4-methylphenylimino)methyl]-2-phenol. Crystal structure of diisothiocyanatodimethylbis〈1-[(4-methylphenylimino)methyl]-2- phenol〉tin(IV), me₂sn(ncs)₂ · [hoc₆h₄ch:Nc₆h₄ch₃] ₂

Doi:10.1016/0277-5387(96)00147-7
(1996)
Convenient Synthesis of Functionalized Dialkyl Ketones and Alkanoylsilanes: 1-(Benzotriazol-1-yl)-1-phenoxyalkanes as Alkanoyl Anion Equivalents

Doi:10.1021/jo960830o
(1996)
A SILICON ANALOG OF A SYMPATHOMIMETIC AMINE.

Doi:10.1021/jm00334a035
(1964)

Article Doi