A study of 3-amino-N-hydroxypropanesulfonamide derivatives as potential GABA(B) agonists and their fragmentation to 3-aminopropanesulfinic acid

DOI: 10.1016/0960-894X(96)00307-1

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1709 - 1714 (1996)

Update date:2022-08-04

Topics:

Authors:

Shue, Ho-Jane

Chen, Xiao

Blythin, David J.

Carruthers, Nicholas I.

Spitler, James M.

Wong, Shing-Chun

Chapman, Richard W.

Rizzo, Charles

West, Robert

She, Hoyan S.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/0960-894X(96)00307-1

A series of 3-amino-N-hydroxypropanesulfonamide analogs were prepared. Several compounds showed potent binding at the GABA(B) receptor and were active in an in vitro functional assay. The GABA(B) activity of these compounds appeared to be due to the fragmented product, 3-aminopropanesulfinic acid.

Full text of DOI:10.1016/0960-894X(96)00307-1

Products guided by the article

Product name:3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-propane-1-sulfonic acid benzyloxy-amide

Cas No:181510-07-6

R&D Labs maybe for 181510-07-6

SuZhou Yacoo Science Co., Ltd

Contact:86-512-87182055

Address:No.128 Fangzhou Rd, Suzhou Industrial Park, China, 215125, China
ClickChem Technology Co., Limited

Contact:+86-0310-6519966/0531-52893837

Address:No.750 Shunhua Road, High-Tech Zone, Jinan city, Shandong China
Dayang Chem (Hangzhou) Co.,Ltd.

website:http://www.dycnchem.com

Contact:+86-571-88938639

Address:9/F, Unit 2 Changdi Torch Building, 259# WenSan Road, Xihu District, Hangzhou City 310012, P.R.China
Chongqing KonAo Health Co.,Ltd

Contact:13687578375

Address:wuhan hubei china
Taizhou Green Peptide Trading Co., Ltd.

Contact:13736652831

Address:Room 1501, No71, Yuehe Road, Taizhou City, Zhejiang Province, China

Relevant to this article

Homogeneous hydrogenation with new cationic ruthenium(II) complexes of [RuH(CO)(NCCH₃)(PPh₃)₂(diphos)]⁺ and [RuH(CO)(NCCH₃)(PPh₃)(diphos)]⁺. Crystal structure of [RuH(CO)(NCCH₃)(PPh₃) (Fe(η⁵-C₅H₄PPh₂) ₂)][BF₄]

Doi:10.1016/0277-5387(96)00103-9
(1996)
Reactions of (σ-alkynyl)platinum complexes with [Pd(η³-C₃H₅)Cl]₂. Synthesis of bis(η²-alkyne)(η³-allyl)palladiuin(II) complexes. Crystal and molecular structure

Doi:10.1021/om9603326
(1996)
Synthesis and electrospray mass spectrometry of platinum(ii) complexes derived from thiourea dianions and the x-ray structure of [pt{nmec(=ncn)s}(cod)] (cod = cyclo-octa-1,5-diene)

Doi:10.1016/0277-5387(96)00133-7
(1996)
Inner sphere complexes derived from the coordinate interactions of tin(IV) isothiocyanate moieties with 1-[(4-methylphenylimino)methyl]-2-phenol. Crystal structure of diisothiocyanatodimethylbis〈1-[(4-methylphenylimino)methyl]-2- phenol〉tin(IV), me₂sn(ncs)₂ · [hoc₆h₄ch:Nc₆h₄ch₃] ₂

Doi:10.1016/0277-5387(96)00147-7
(1996)
Convenient Synthesis of Functionalized Dialkyl Ketones and Alkanoylsilanes: 1-(Benzotriazol-1-yl)-1-phenoxyalkanes as Alkanoyl Anion Equivalents

Doi:10.1021/jo960830o
(1996)
A SILICON ANALOG OF A SYMPATHOMIMETIC AMINE.

Doi:10.1021/jm00334a035
(1964)

Article Doi