A study of 3-amino-N-hydroxypropanesulfonamide derivatives as potential GABA(B) agonists and their fragmentation to 3-aminopropanesulfinic acid

DOI: 10.1016/0960-894X(96)00307-1

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1709 - 1714 (1996)

Update date:2022-08-04

Topics:

Authors:

Shue, Ho-Jane

Chen, Xiao

Blythin, David J.

Carruthers, Nicholas I.

Spitler, James M.

Wong, Shing-Chun

Chapman, Richard W.

Rizzo, Charles

West, Robert

She, Hoyan S.

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Article abstract of DOI:10.1016/0960-894X(96)00307-1

A series of 3-amino-N-hydroxypropanesulfonamide analogs were prepared. Several compounds showed potent binding at the GABA(B) receptor and were active in an in vitro functional assay. The GABA(B) activity of these compounds appeared to be due to the fragmented product, 3-aminopropanesulfinic acid.

Full text of DOI:10.1016/0960-894X(96)00307-1

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