Stereoselective preparation of (5E)- and (5Z)-5-benzylidene-3-methyl-3-pyrrolin-2-ones. Application to the synthesis of ampullicine and isoampullicine

Article abstract of DOI:10.1016/0040-4039(96)01232-4

The application of N-Boc-5-phosphoranylidene- and N-Boc-5-diethylphosphonate-3-methyl-3-pyrrolin-2-ones to the stereoselective synthesis of (5E)- and (5Z)-3-methyl-5-benzylidene-3-pyrrolin-2-ones is examined. The stereoselective synthesis of the growth regulators Ampullicin and Isoampullicin by using both Wittig intermediates has also been achieved.